Hierarchical cortical transcriptome disorganization in autism
نویسندگان
چکیده
منابع مشابه
Title : Hierarchical cortical transcriptome disorganization in autism
Affiliations 1 Center for Applied Neuroscience, Department of Psychology, University of Cyprus, Nicosia, Cyprus 2 Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom 3 Department of Neuroscience, University of California, San Diego, San Diego CA, USA 4 Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA,...
متن کاملHierarchical cortical transcriptome disorganization in autism
BACKGROUND Autism spectrum disorders (ASD) are etiologically heterogeneous and complex. Functional genomics work has begun to identify a diverse array of dysregulated transcriptomic programs (e.g., synaptic, immune, cell cycle, DNA damage, WNT signaling, cortical patterning and differentiation) potentially involved in ASD brain abnormalities during childhood and adulthood. However, it remains u...
متن کاملPatches of disorganization in the neocortex of children with autism.
BACKGROUND Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development. METHODS To systematically examine neocorti...
متن کاملTranscriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia
Autism (AUT), schizophrenia (SCZ) and bipolar disorder (BPD) are three highly heritable neuropsychiatric conditions. Clinical similarities and genetic overlap between the three disorders have been reported; however, the causes and the downstream effects of this overlap remain elusive. By analyzing transcriptomic RNA-sequencing data generated from post-mortem cortical brain tissues from AUT, SCZ...
متن کاملMolecular Disorganization of Axons Adjacent to Human Cortical Microinfarcts
Cortical microinfarcts (CMIs) are microscopically identified wedge-shaped ischemic lesions that occur at or near the cortical surface and result from occlusion of penetrating arterioles. These microscopic lesions can be observed with high-resolution magnetic resonance imaging in aging brains and in patients with cerebrovascular disease. Recent studies have suggested that strategically located m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Autism
سال: 2017
ISSN: 2040-2392
DOI: 10.1186/s13229-017-0147-7